Patogenetika, Investigasi, dan Terapi Penyakit Mitokondria

Alan, T. W., Choo-Kang, Lynn, S., Geoffrey, A. T., Mark, E. D., Sarcpreet, S. S., Teressa, M. W., Patrick, F. C., Douglass, M. T., & Mark, W. 2002. Defining the importance of mitochondrial gene defects in maternally inherited diabetes by sequencing the entire mitochondrial genome. Brief Genetics Report. Diabetes, 51: 2317-2320.

Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H., Coulson, A. R., & Drouin, J. 1981. Sequence and organization of the human mitochondrial genome. Nature 290: 457–65.

Anonim. 2003. Mutasi DNA mitokondria penyebab diabetes melitus. Diakses melalui <http://www.gklinis.com/>, [10/11/2003].

Bell, A. J. 2004. MELAS Syndrome: Overview and case study. Department of EEG and Clinical Neurophysiology. Seattle.

Brown, G. K., Otero, L. J., LeGris, M., & Brown, R. M. 1994. Pyruvate dehydrogenase deficiency. J Med Genet. 31: 875-9.

Bruno, C., Minetti, C., & Tang, Y. 1998. Primary adrenal insufficiency in a child with mitochondrial DNA deletion. J Inherit Metab Dis. 21: 155-161.

Bruyn, G. W., Bots, G. T., Went, L. N., & Klinkhamer, P. J. 1992. Hereditary spastic Dystonia with Leber’s Hereditary Optic Neuropathy: Neuropathological findings. J Neurol Sci. 113: 55-61.

Celeste, A., Difilippantonio, S., & Difilippantonio, M.J. 2003. H2AX Haploinsufficiency Modifies Genomic Stability and tumor susceptibility. Cell. 114(3): 371–383.

Chinnery, P.F. 2003. Mitochondrial disorder overview. Department of Neurology University of Newcastle. Newcastle.

Chinnery, P. F., Howell, N., Andrews, R. M., & Turnbull, D. M. 1999. Clinical mithocondrial genetics. Q. J. Med Genet. 36: 425-436.

Chinnery, P. F., Howell, N., Lightowlers, R. N., & Turnbull, D. M. 1998. MELAS and MERRF: The relationship between maternal

mutation load and the frequency of clinically affected offspring. Brain. 121: 1889-994.

Chinnery, P. F., Howell, N., Lightowlers, R. N., & Turnbull, D. M. 1997. Molecular pathology of MELAS and MERRF: the Relationship between mutation load and clinical phenotyphes. Brain. 120: 1713-21.

Chinnery, P. F. & Turnbull, D. M. 1998. Vomitting, anorexia and mitochondrial DNA disease. Lancet. 351:448.

Chinnery, P. F. & Turnbull, D. M. 1997. Mitochondrial medicine. Q. J. Med. 90: 657-66

Chinnery, P. F. & Turnbull, D. M. 1997. The clinical features, investigation and management of patients with mitochondrial DNA defects. J Neurosurg Psychiatry. 63: 559-63.

Damian, M. S., Seibel, P., & Reichmann, H. 1995. Clinical spectrum of the MELAS mutation in a large pedigree. Acta Neurol Scand. 92: 409-15.

De Vries L., Elenko, E., Hubler, L., Jones T.L & Farquhar M.G.1996. GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. Proc Natl Acad Sci U S A. (26):15203-8

DiMauro, S. & Schon, E. A. 1990. Mitochondrial encephalomyopathies. Neurological Clinics. 8: 483-506.

Dr'ge, W. 2002. Free Radicals in the physiological control of cell function. Physiol Rev. 82: 47–95.

Fajans, S. S., Bell, G. I., & Polonsky, K. S. 2001. Molecular mechanisms and clinical pathophysiology of Maturity-Onset Diabetes of The Young. N Engl Med J. 345: 971–980.

Finsterer, J. 2007. Genetic, pathogenetic, and phenotypic implication of the mitochondrial A3243G tRNALeu(UUR) mutation. Acta Neurol Scand. 116: 1–14.

Filosto M, Mancuso M, Vives-Bauza C et al (2003) Lack of paternal inheritance of muscle mitochondrial DNA in sporadic mitochondrial myopathies. Ann Neurol. 54:524–526.

Gardner, J. C., Goliath, R., & Viljoen, D. 1997. Familial streptomycin ototoxicity in a South African family: a Mitochondrial disorder. J Med Genet. 34: 904-6.

Garrido, C., Galluzzi, L., Brunet, M., Puig P.E., Didelot, C. & Kroemer, G. 2006. Mechanisms of cytochrome c release from mitochondria. Cell Death and Differentiation. 13: 1423–1433.

Gerbitz, K. D., van den Ouweland, J. M. W., Maasen, J. A., & Jaksch, M. 1995. Mitochondrial diabetes: a Review. Biochem Biophys Acta. 1271: 253-60.

Green, K., Brand, M. D., & Murphy, M. P., 2004. Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes. 53 (Suppl1): S110–S118.

Griffiths, A. J. F., Miller, J. H., Suzuki, D. T., Lewontin, R. C., & Gelbart, W. M. 1993. An introduction to genetic analysis. Fifth Edition. New York. W. H. Freeman and Company.

Guillausseau, P. J., Massin, P., Dubois-LaForgue, D., Timsit, J., Virally, M., & Gin, H. 2001. Maternally inherited diabetes and deafness: a multicenter study. Ann Intern Med. 134: 721-8.

Hammans, S. R., Sweeney, M.G., Hanna, M. G., Brockington, M., Morgan-Hughes, J. A., & Harding, A. E. 1995. The mitochondrial DNA transfer RNALeu(UUR) A to G (3243) mutation, A clinical and genetic study. Brain. 118: 721-734.

Hammans, S. R., Sweeny, M. G., & Brockington, M. 1993. The Mitochondrial DNA Transfer RNA (Lys)A G (8344) mutation and the syndrome of Myoclonic Epilepsy with Ragged Red Fibres (MERRF). Relationship of clinical phenotype to proportion of mutant mitochondrial DNA. Brain. 116(pt3): 617-32.

Hanna, M. G., Vaughan, J. R., & Silburn, P. A. 1997. Two unusual clinical presentations of the mitochondrial dna a3243g point mutation in adult neurological practice. J Neurol Neurosurg Psychiatry. 62: 544-5.

Hao, R., Yao, Y. N., Zeng, Y. G., Xu, M. G., & Wang, E. D. 2004. Reduction of mitochondrial tRNALeu(UUR) aminoacylation by some melas-associated mutations. FEBS Left. 578: 135-9.

Helm, M., Florentz, C., Chomyn, A., & Attardi, G. 1998. Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR). Nucleic Acida Res. 27: 756-63.

Henderson, G. V., Kittner, S. J., & Johns, D. R. 1997. An incidence study of stroke secondary to MELAS in the young. Neurology. 48: A403.

Hesterlee, S. 2001. Mitochondrial disease in perspective symptoms. diagnosis and hope for the future. melalui www.cla-dca.gcrc.ufl.edu/cla-dca/physinfo. html, [14/12/2005].

Hirano, M., Pavlakis, S. G. 1994. Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS): current concepts. J Child Neurol. 9: 4-13.

Hirano, M., Ricci, E., & Koenigsberger, M. R. 1992. MELAS: An original case and clinical criteria for diagnosis. Neuromuscular Disorder. 2: 125-35.

Holt, I. J., Harding, A. E., Petty, R. K., & Morgan-Hughes, J. A. 1990. A New mitochondrial disease associated with mitochondrial DNA heteroplasmy. Am J Hum Genet. 46: 428-33.

Holt, I. J., Miller, D. H., & Harding, A. E. 1989. Genetic heterogeneity and mitochondrial dna heteroplasmy in Leber’s Hereditary Optic Neuropathy. J Med Genet. 26: 739-743.

Holt, I., Harding, A. E., & Morgan-Hughes, J. A 1988. Deletion of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature. 331: 717-19.

Howell, N. 1997. Leber’s Hereditary Optic Neuropathy: How Do Mitochondrial DNA Mutations Cause Degeneration of the optic nerve? J Bioenerg Biomembr. 29: 165-73.

Howell, N., Kubacka, I., Smith, R., Frerman, F., Parks, J. K., & Parker, W. D., Jr. 1996. Association of the mitochondrial 8344 MERRF mutation with maternally inherited spinocerecellar degeneration and leigh disease. Neurology. 46: 219-222.

Hudson, G., Deschauer, M., Busse, K., Zierz, S., & Chinnery, P. F. 2005. Sensory ataxic neuropathy due to a novel C10Orf2 mutation with probable germline mosaicism. Neurology. 64: 371-373.

Jackson, M. J., Schaefer, J. A., Johnson, M. A., Morris, A. A. M., Turnbull, D. M., & Bindoff, L. A. 1995. Presentation and clinical investigation of mitochondrial and respiratory chain disease. Brain. 118: 339-357.

Johns, D. R. 1995. Mitochondrial DNA and disease. The New England Journal of Medicine (NEJM). 348: 2656-2668.

Johnson, C.C., Barron, E.J., Kauffman, E.G., Arthur, M.A., Fawcett, P.J., & Yasuda, M.K. 1996. Middle cretaceous reef collapse linked to ocean heat transport. Geology. 24(4), 376–380.

Kadowaki, T., Kadowaki, H., Mori, Y., Tobe, S., Sakuta, R., Suzuki, Y., Tanabe Y., Sakura, H., Awata, T., Goto, Y., Hayakawa, T., Matsuoka, K., Kawamori, R., Kamada, T., Horai, S., Nonaka, I., Hagura, R., Akanuma, Y., & Yazaki, Y. 1994. A subtype of diabetes melitus associated with a mutation of mitochondrial DNA. N Engl J Med. 330: 962–968.

Kaukonen, J., Juselius, J. K., & Tiranti, V. 2000. Role of adenine nucleotide translocator 1 in mtDNA Maintenance. Science. 289: 782-785.

Kiechl, S., Horvath, R., Luoma, P. 2004. Two Families with autosomal dominant progressive external ophtalmoplegia. J Neurol Neurosurg Psychiatry. 75: 1125-1128.

Kimata, K. G., Gordan, L., Ajax, E. T., Davis, P. H., & Grabowski, T. 1998. A Case of late onset MELAS. Arch Neurol. 55: 722-5.

Kirino, Y., Yasukawa, T., Ohta, S., Akira, S., Ishihara, K., Watanabe, K., & Suzuki, T. 2004, Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA form human mitochondrial disease. PNAS. 101-42: 15070-15075.

Kleiner, I. M., Medvidovic, E. P., Renar, I. P., Metelko, Z., Kusec, R., Gabrilovac, J., & Boranic, M. 2004. A pilot study of mitochondrial DNA point mutation A3243G in a sampel of Croatian patients having type-2 diabetes melitus associated with maternal heritance. Acta Diabetol. 41: 179-184.

Kurata, S., Weixlbaumer, A., Ohtsuki, T., Shimazaki, T., Wada, T., Kirino, Y., Takai, K., Watanabe, K., Ramakrishnan, V., & Suzuki,

T. 2008. modified uridines with c5-methylene substituents at the first position of the tRNA anticodon stabilize U_G Wobble pairing during decoding. The Journal Of Biological Chemistry. 283: 18801–18811.

Larsson, N. G. & Clayton, D. A. 1995. Molecular genetic aspects of human mitochondrial disorders. Annu Rev Genet. 29: 151-78.

Lehtinen, S. K. 2001. Genetic selection in human mitochondria. Acta Universitatis Tamperensis, Tampere, pp: 11-32. Lewin, B. 1997. Gens VI. Oxford University Press and Cell Press. New York.

Lightowlers, R. N., Chinnery, P. F., Turnbull, D. M., & Howell, N. 1997. mammalian mitochondrial genetics: heredity, heteroplasmy, and disease. Trends Genet. 13: 450-5.

Liou, C. W., Huang, C., & Wei, Y. H. 2001. Molecular analysis of diabetes melitus-associated A3243G mitochondrial DNA mutation in Taiwan cases. Diab. Res. and Clin. Practice 54 Suppl. 2: S39-S43.

Lynn, S., Wardell, T., Johnson, M.A., Chinnery, P.F., Daly, M.E., Walker, M., & Turnbull, D.M. 1998. Mithochondrial diabetes: investigation and identification of a novel mutation. Brief Genetics Report. Diabetes. 47: 1800-1804.

Maassen, J. A., t’Hart, L. M., van, Essen, E., Heine, R. J., Nijpels, G., Roshan, S., Tafrechi, J., Raap, A. K., Janssen, G. M. C., & Lemkes, H. P. J. 2004. Mitochondrial diabetes: molecular mechanisms and clinical presentation, diabetes. 52: S103-S109.

Maassen, J. & Kadowaki, T. 1996. Maternally inherited diabetes and deafness: a new diabetes subtype. Diabetologia. 39: 375-82.

Maksum, I.P. 2017. PCR dalam Investigasi Penyakit Mitokondria. Alqaprint Jatinangor, Cakrawala Baru Dunia Buku.

Maksum, I. P., Oemardi, M., Sriwidodo, Sidik, A., Amalia, R., & Sasongko, H. 2007. Penggunaan metode PASA mismatch tiga basa untuk pencarian fenotipe MIDD pada pasien diabetes melitus tipe 2 di Indonesia, Seminar Nasional Ikatan Ilmu Faal Indonesia.

Maksum, I. P., Sidik, A., Subroto, T., Prihartanto, B., & Subarnas, A. 2005. Analisis diabetes melitus tipe 2 menggunakan PASA dan SSCP dan studi pola pewarisannya, Laporan Penelitian.

Maksum, I. P., Siti F. Alchumaira, Dian S. Kamara, Saadah D. Rachman, S. Komalaningsih. 2015. the relation of mitochondrial dna mutation with mitochondrial diseases in coding region, Procedia Chemistry. 17: 84–92.

Maksum, I. P., Sriwidodo, S. Gaffar, K. Hassan, T. Subroto, S &. Soemitro. 2017. Teknik Biologi Molekular. Alqaprint Jatinangor, Cakrawala Baru Dunia Buku.

Maksum, I. P., Suprijana, O., Subroto, T., Prihartanto, B., & Subarnas, A. 2004. Penggunaan PCR-RFLP dan teknik dna rekombinan untuk analisis diabetes melitus tipe-2, Laporan Penelitian Hibah Bersaing XIII.

Man, P. Y., Griffiths P. G., Brown, D. T., Howell, N., Turnbull, D. M., & Chinnery, P. F. 2003. The Epidemiology of Leber’s Hereditary Optic Neuropathy in the North East of England. Am J Human Genet. 72: 333-39.

Mansergh, F. C., Millington-Ward, S., & Kennan, A. 1999. Retinitis Pigmentosa and progressive sensorineural hearing loss caused by a c12258A Mutation in the Mitochondrial MTTS2 Gene. Am J Hum Genet. 64: 971-85.

Mathews, C. K. & Holde, K. E. 1999. Biochemistry. The Benjamin/Cummings Publishing Company, Inc. New York.

Matthews, P. M., Tampieri, D., & Berkovic, S. F. 1991. Magnetic resonance imaging shows spesific abnormalities int the MELAS syndrome. Neurology. 41: 1043-6.

Marzuki S., Genetic diversity and human diseases. 2000. Eijkman Institute for Molecular Biology. Jakarta.

McFadden, G. 2005. Poxvirus tropism. Nature reviews. Microbiology. 3(3), 201–13.

Meissner, C., von Wurmb, N., Schimansky, B. & Oechmichen, M. 1999. Estimation of age at death based on quantitation of the 4977-bp deletion of human mitochondrial DNA in skeletal muscle, Forensic Science International. 105: 115-124.

Melov, S. 2000. Mitochondrial Oxidative Stress. physiologic consequences and potential for a role in aging. Ann NY Acad Sci. 908: 219–225.

Milligan, J. R., Aguilera, J. A., & Ward J. F. 1993. variation of singlestrand break yield with scavenger concentration for the SV40

Minichromosome Irradiated in Aqueous Solution. Radiat Res. 133 (2): 158–162.

Mitomap. 2010.Human Mitochondrial Genome Database .http://www.mitomap.org/.

Mohora, M., Greabu, M., Muscurel, C., Data, C., & Totan, A. 2007. the sources and the targets of oxidative stress in the etiology of diabetic complication. Romanian J. Biophys. 17: 63-84.

Morases, C. T., DiMauro, S., & Zeviani, M. 1989. mitochondrial dna deletions in progressive external ophtalmoplegia and Kearns-Sayre syndrome. New England Journal Medicine. 320: 1293-9.

Morten, K. J., Cooper, J. M., Brown, G. K., Lake, B. D., Pike, D., & Poulton, J. 1993. a new point mutation associated with mitochondrial encephalopathy. Hum Mol Genet. 2: 2081-7.

Munnich, A., Rotig, A., & Chretien, D. 1996. Clinical presentations of mtitochondrial dissorders in childhood. J Inherit Metab Dis. 19: 521-7.

Nelson, D. & Cox, M. 2008. Lehninger principles of biochemistry (4th ed.). 6th ed. USA: University of Wisconsin Press.

Nikoskelainen, E. K. 1994. Clinical picture of LHON. Clin Neurosci. 2: 115-20.

Noer, A.S., Martasih, F., Mulyani, S., Muktiningsih, & Wirahadikusumah, M. 1994. analisis varian urutan nukleotida d - loop mtdna manusia dari berbagai daerah di indonesia (The analysis of human mtDNA D-loop nucleotide sequence in several regions in Indonesia), Prosiding Seminar Bersama UKM-ITB I.

Nomiyama, T., Tanaka, Y., Hattori, N., Nishimaki, K., Nagasaka, K., Kawamori, R., & Ohta, S. 2002. Accumulation of somatic mutation in mitochondrial DNA extracted from peripheral blood cells in diabetic patients. Diabetologia. 45: 1577-1583.

Ohkubo, K., Yamano, A., Nagashima, M., Mori, Y., Anzai, K., Akehi, Y., Nomiyama, R., Asano, T., Urae, A., & Ono, J. 2001. mitochondrial gene mutations in the tRNALeu(UUR) Region and diabetes: prevalence and clinical phenotypes in Japan. Clin. Chem. 47: 1641–1648.

Olsson, C. 2001. Quantitative analysis of disease associated mutations and sequence variants. Acta Universitatis Upsaliensis. Pp: 4-22.

Orita, M., Iwahana, H., Kanazawa, H., Hayashi, K., & Sekiya, T. 1989. Detection of polymorphismd of human DNA by gel electrophoresis as single-strand conformation polymorphism. Proc. Natl. Acad. Sci. 86: 2766-2770.

Owen, K., Sride, A., Ellard, S., & Hattersley, A.T. 2003. Etiological Investigation of diabetes in young adults presenting with apparent type 2 diabetes, Diabetes Care. 26(7): 2088-2093.

Pieczenik, S. & Neustadt, R., J. 2007. Mitochondrial dysfunction and molecular pathways of disease. Experimental and Molecular Pathology. 83: 84-92.

Rotig, A., Cormier, V., Blanche, S., Bonnefont, J. P., & Ledeist, F. 1990. Pearson’s marrow pancreas syndrome. A Multiyistem Mitochondrial Disorder of Infancy. J Clin Ivest. 86: 1601-8.

Rossignol, R., Faustin, B., Rocher, C., Malgat, M., Mazat, J., & Letellier, T. 2003. Mitochondrial threshold effects. Biochem. J. 370: 751–762.

Roy, M. D., Wittenhagen, L. M., & Kelley S. O. 2005. Structural probing of a pathogenic tRNA dimer. RNA. 11: 254-260.

Santosa, Soenarto, & Hadi, S. 2005. Pengenalan Miopati Mitokondria. Universitas Diponegoro. Semarang.

Santorelli, F. M. & Tessa, A. 2004. Neuropathy, Ataxia and Retinitis Pigmentosa (NARP) syndrome. Orphanet Ensiklopedia.

Schapira, A. H. V. 2006. Mitochondrial disease. Lancet. 368: 70-82.

Shoffner, J. M., Brown, M. D., & Stugard, C. 1995. Leber’s Hereditary Optic Neuropathy plus dystonia is caused by a mitochondrial DNA point mutation. Ann Neurol. 38: 163-9.

Shoffner, J. M., Voljavec, A. S., Dixon, J., Kaufman, A., Wallace, D. C., & Mitch, W. E. 1995. Renal amino acid transport in adults with oxidative phosphorylation diseases. Kidney Int. 47: 1101-7.

Shoffner, J. M., Lott, M. T., Lezza, A. M., Seibel, P., Ballinger, S. W., & Wallace, D. C. 1990. Myoclonic Epilepsy and Ragged-Red Fibre Disease (MERRF) is associated with mitochondrial DNA tRNA(Lys) mutation. Cell. 61: 931-7.

Singhal, N., Gupta, B. S., Saigal, R., Makkar, J., & Mathur R. 2000. Mitochondrial diseases: an overview of genetics, pathogenesis, clinicals, features and an approach to diagnosis and treatments. Journal of Postgraduate Medicine. 43: 224-230.

So, W. Y., Ng, M. C. Y., Lee, S. C., Sanke, T., Lee, H. K., & Chan, J. C. N. 2000. Genetic of type 2 Diabetes Mellitus. HKMJ. 6: 69-75.

Sohm, B., Frugier, M., Brule, H., Olszak, K., Przykorska, A., & Florentz, C. 2003. Towards understanding human mitochondrial leucine aminoacylation identity. J Mol Biol. 328: 995-1010.

Suzuki, Y., Nishimaki, K., Taniyama, M., Muramatsu, T., Atsumi, Y., Matsuoka, K., & Ohta, S. 2004. Acute metabolic cataract as a first manifestation of diabetes mellitus in A 12-year-old girl. Diabetologia. 47: 3.

Takahiro, I & Fumihiko, S. 2005. Pathogenesis of stroke-like episodes in MELAS: analysis neurovascular cellular mechanisms.

Taniyama, Y. & Griendling, K. K. 2003. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension. 42: 1075–1081.

Taylor, R. & Turnbull, D. 2005. Mitochondrial DNA transcription: regulating the power supply. Cell. 130(2): 211-213.

Taylor, R. W., Taylor, G. A., Durham, S. E., & Turnbull, D. M. 2001. The determination of complete human mitochondrial DNA sequences in single cells: implications for the study of somatic mitochondrial DNA point mutations. Nucleic Acids Research. 29(15): e74.

Taylor, R. W., Birch-Machin, M. A., & Schaefer, J. 1996. Deficiency of complex II of the mitochondrial respiratory chain in late-onset optic atrophy and ataxia. Ann Neurol. 39: 224-32.

Van der Knaap, M. S., Jakobs, C., & Valk, J. 1996. magnetic resonance imaging in lactic acidosis. J Inherit Metab Dis. 19: 535-47.

Vasquez-Vivar, J., Kalyanaraman, B., & Kennedy, M. C. 2000. Mitochondrial aconitase is a source of hydroxyl radical. An Electron Spin Resonance Investigation. J. Biol. Chem. 275(19): 14064–14069.

Vilarinho, L., Santorelli, F. M., Rosas, M. J., Tavares, C., Melo-Pires, M., & DiMauro, S. 1997. The mitochondrial A3243G mutation presenting as severe cardiomyopathy. J Med Genet. 34: 607-9.

Vinson, J.1991. Mitochondrial disease in perspective symptoms. Diagnosis And Hope For The Future.

Wallace, D. C., Zheng, X., Lott, M. T., Shoffner, J. M., Hodge, J. A., Kelley, R. I., Epstein, C. M., & Hopkins, L.C. 1988. Familial mitochondrial encephalomyopathy (MERRF): Genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease. Cell. 66: 601–610.

Wei, Y. H. & Lee, H. C. 2003. edited by Spiegel H. E, Nowacki G, Hsiao K. J. Mitochondrial DNA mutations and oxidative stress 84-128.

White-Cooper, H., Schäfer, M. a, Alphey, L.S., & Fuller, M.T. 1998.

Transcriptional and post-transcriptional control mechanisms coordinate the onset of spermatid differentiation with meiosis I in Drosophila. Development (Cambridge, England). 125(1): 125–134.

Widowati, W. 2008. Potensi antioksidan sebagai antidiabetes. Jurnal Kedokteran Maranatha. 7(2): 193-202.

Wilson, F. H., Hariri, A., & Farhi, A. 2004. A Cluster of metabolic defects caused by mutation in a mitochondrial tRNA. Science. 306: 1190-94.

Wilson, M. R., DiZinno, J. A., Polanskey, D., Replogle, J., & Budowle, B. 1995. Validation of mitochondrial DNA sequencing for forensic casework analysis. International Journal of Legal Medicine. 108(2): 68- 74.

Wittenhagen, L. M. & Kelley, S. O. 2002. Dimerization of a pathogenic human mitochondrial tRNA. Nat. Struct. Biol. 9: 586-590

Wray, S. H., Provenzale, J. M., Johns, D. R., & Thulborn, K. R. 1995. MR of the brain in mitochondrial myopathy. Am J Neuroradiol. B16: 1167-73.

Yasukawa, T., Suzuki, T., Ueda, T., Ohta, S., & Watanabe, K. 2005. Modification defect at anticodon wobble nucleotide of mitochondrial tRNAsLeu(UUR) with patoghenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. J Biol Chem. 275: 4251-7.