PENDEKATAN METABOLOGENOMIK DALAM FERMENTASI TERKONTROL UNTUK MENDUKUNG KEMANDIRIAN BAHAN ALAM DAN PANGAN FUNGSIONAL DI INDONESIA

Agolino, G., Cristofolini, M., Vaccalluzzo, A., Tagliazucchi, D., Cattivelli, A., Pino, A., Caggia, C., Solieri, L., & Randazzo, C. L. (2025). Genome mining and characterization of two novel Lacticaseibacillus rhamnosus probiotic candidates with bile salt hydrolase activity. Biomolecules, 15(1), 86. https://doi.org/10.3390/biom15010086

Amaral, E. de P., Entringer, T. L., Veloso, T. G. R., da Luz, J. M. R., Pimenta, L. H. B., Moreli, A. P., Pereira, L. L., & da Silva, M. de C. S. (2026). Microbial dynamics and impact of controlled fermentation in Coffea arabica over 288 h. Food Bioscience, 75, 108081. https://doi.org/10.1016/j.fbio.2025.108081

Andrade-Espinoza, B. A., Arratia-Quijada, J., Nuño, K., Ruíz-Santoyo, V., & Contreras, L. F. (2025). Metabolomics in food fermentation and designing functional foods. In Microbial Metabolomics (pp. 235–247). Springer Nature Singapore. https://doi.org/10.1007/978-981-96-4824-5_11

Anshory, L., Setiarto, R., Andrianto, D., & Frediansyah, A. (2026). Microbiological dimensions symbiotic culture of bacteria and yeast (SCOBY) and functional properties of kombucha tea fermented drink. Review in Agricultural Sciences, 14(1), 68–91. https://doi.org/10.7831/ras.14.1_68

Ariantari, N. P., Putra, I. P. Y. A., Wiprayoga, I. P. P., Frediansyah, A., Putri, N. W. P. S., Suari, A. A. I. P., ... & Pharmawati, M. (2026). Draft genome sequence of endophytic fungus Fusarium proliferatum ZO-L2-4 and analysis of its secondary metabolite biosynthetic potential. Journal of Applied Pharmaceutical Science, 16(4), 275–287. https://doi.org/10.7324/JAPS.2026.234783

Anwar, M., Damayanti, E., Sofyan, A., Frediansyah, A., & Romadhoni, F. (2021). Metode untuk memproduksi kitosan dengan media tumbuh jamur (Patent No. IDP000074797). Direktorat Jenderal Kekayaan Intelektual.

Basuki, W., Sunaryanto, R., Frediansyah, A., Layly, I. R., Yusnitati, Giarni, R., & Shodiq, A. W. (2023). Isolation and characterization of Thraustochytrium Trk-23 producing docosahexaenoic acid from North Kalimantan, Indonesia. Pakistan Journal of Biological Sciences, 26(11), 567–575. https://doi.org/10.3923/pjbs.2023.567.575

Biofin. (2025). Indonesia. BIOFIN: The Biodiversity Finance Initiative. https://www.biofin.org/indonesia

Bode, H. B., Bethe, B., Höfs, R., & Zeeck, A. (2002). Big effects from small changes: Possible ways to explore nature’s chemical diversity. ChemBioChem, 3(7), 619–627. https://doi.org/10.1002/1439-7633(20020703)3:7<619::AID-CBIC619>3.0.CO;2-9

Boer, R., Dewi, R. G., Siagian, U. W. R., Ardiansyah, M., Sunkar, A., & Ratnasari, B. (2021). Indonesia: Third Biennial Update Report (No. 1). Minister of Environment and Forestry.

Buchmann, A., Eitel, M., Koch, P., Schwarz, P. N., Stegmann, E., Wohlleben, W., Wolanski, M., Krawiec, M., Zakrzewska-Czerwinska, J., Mendez, C., Botas, A., Nunez, L. E., Morís, F., Cortes, J., & Gross, H. (2016). High-quality draft genome sequence of the actinobacterium Nocardia terpenica IFM 0406, producer of the immunosuppressant brasilicardins, using illumina and PacBio technologies. Genome Announcements, 4(6), e01391-16. https://doi.org/10.1128/genomeA.01391-16

Chen, J., Frediansyah, A., Männle, D., Straetener, J., Brötz-Oesterhelt, H., Ziemert, N., Kaysser, L., & Gross, H. (2020). New nocobactin derivatives with antimuscarinic activity, terpenibactins A–C, revealed by genome mining of Nocardia terpenica IFM 0406. ChemBioChem, 21(15), 2205–2213. https://doi.org/10.1002/cbic.202000062

Chiang, Y.-M., Chang, S.-L., Oakley, B. R., & Wang, C. C. C. (2011). Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Current Opinion in Chemical Biology, 15(1), 137–143. https://doi.org/10.1016/j.cbpa.2010.10.011

Cimermancic, P., Medema, M. H., Claesen, J., Kurita, K., Wieland Brown, L. C., Mavrommatis, K., Pati, A., Godfrey, P. A., Koehrsen, M., Clardy, J., Birren, B. W., Takano, E., Sali, A., Linington, R. G., & Fischbach, M. A. (2014). Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell, 158(2), 412–421. https://doi.org/10.1016/j.cell.2014.06.034

Dhama, K., Nainu, F., Frediansyah, A., Yatoo, M. I., Mohapatra, R. K., Chakraborty, S., Zhou, H., Islam, M. R., Mamada, S. S., Kusuma, H. I., Rabaan, A. A., Alhumaid, S., Mutair, A. Al, Iqhrammullah, M., Al-Tawfiq, J. A., Mohaini, M. Al, Alsalman, A. J., Tuli, H. S., Chakraborty, C., & Harapan, H. (2023). Global emerging Omicron variant of SARS-CoV-2: Impacts, challenges and strategies. Journal of Infection and Public Health, 16(1), 4–14. https://doi.org/10.1016/j.jiph.2022.11.024

Fahriani, M., Ilmawan, M., Fajar, J. K., Maliga, H. A., Frediansyah, A., Masyeni, S., Yusuf, H., Nainu, F., Rosiello, F., Sirinam, S., Keam, S., & Ophinni, Y. (2021). Persistence of long COVID symptoms in COVID-19 survivors worldwide and its potential pathogenesis—A systematic review and meta-analysis. Narra J, 1(2). https://doi.org/10.52225/narraj.v1i2.36

Fitrianto, N., Nufus, H., Frediansyah, A., Aziz, S. A. A., Damayanti, E., Fauzan, I. A., Rosyida, V. T., Safitri, I. O., Suryani, R., Sunaryanto, R., Wibowo, N. A., & Palindung, L. S. (2025). Free radical scavenging and antimicrobial activities of lactic acid bacteria isolated from Indonesian traditional fermented soy food against food-borne pathogens. IOP Conference Series: Earth and Environmental Science, 1476(1), 012052. https://doi.org/10.1088/1755-1315/1476/1/012052

FMI. (2025). Bioactive ingredient market growth – Functional nutrition & industry trends 2025 to 2035. Future Market Insights. https://www.futuremarketinsights.com/reports/bioactive-ingredient-market

Frediansyah, A. (2012). Studi komparatif anggota Aspergillus kelompok Flavi pada bioproses kecap kedelai. In I. Ratnaningtyas, A. Mumpuni, U. Dwiputranto, N. Ekowati, J. Safitri, Gratiana, A. Nuryanto, R. S. Dewi, & U. Susilo (Eds.), Seminar Nasional Mikologi: Biodiversitas dan Bioteknologi Sumberdaya Hayati Fungi. Universitas Jendral Soedirman.

Frediansyah, A. (2014). Infant botulism effect of Clostridium and the involvement of sudden infant death syndrome (SIDS): Review. European Academic Research, 1(10), 3248–3257.

Frediansyah, A. (2018). Microbial fermentation as means of improving cassava production in Indonesia. In Cassava. IntechOpen. https://doi.org/10.5772/intechopen.71966

Frediansyah, A. (2020). Food fermentation: From traditional to scientific communities. In M. Mahendradatta, W. P. Rahayu, U. Santoso, G. Giyatmi, A. Ardiansyah, D. L. N. Fibri, F. Kusnandar, & Y. Witono (Eds.), Current issues of food in Indonesia (1st ed., Vol. 1, pp. 97–99). Interlude.

Frediansyah, A. (2021). The antiviral activity of iota-, kappa-, and lambda-carrageenan against COVID-19: A critical review. Clinical Epidemiology and Global Health, 12, 100826. https://doi.org/10.1016/j.cegh.2021.100826

Frediansyah, A. (2021). The microbiome of cassava (Manihot esculenta). In Cassava - Biology, production, and use. IntechOpen. https://doi.org/10.5772/intechopen.97818

Frediansyah, A. (2024). Growth in traditional fermented soybeans-related research (tempeh, natto, doenjang, chungkookjang, douchi, meju, kinema, oncom, and tauco) from 1928 to 2024, following the omics emergence and trend in functional food. Process Biochemistry, 147, 600–624. https://doi.org/10.1016/j.procbio.2024.11.008

Frediansyah, A. (2025). Bir jawa: History, gastrodiplomacy, and health benefits of a Javanese non-alcoholic beverage. Journal of Ethnic Foods, 12(38). https://doi.org/10.1186/s42779-025-00300-7

Frediansyah, A., & Aziz, S. A. A. (2024). Phytochemical properties of Medinilla speciosa leaf extract and its antibacterial activity against Burkholderia sp. AIP Conference Proceedings, 2957(1). https://doi.org/10.1063/5.0183974

Frediansyah, A., Aziz, S., Ramadaningrum, W. A., & Sunarwidhi, A. A. L. (2021). Mass spectrometry analysis revealed the production of siderophore from Klebsiella oxytoca strain STA01 isolated from sago palm field in Tulehu, Maluku, Indonesia. IOP Conference Series: Earth and Environmental Science, 712(1), 012011. https://doi.org/10.1088/1755-1315/712/1/012011

Frediansyah, A., Azzahra, F. L., & Fitrianto, N. (2023). Antioxidant properties of Syzygium polycephalum leaf extract and its antibacterial activity against Serratia marcescens and Burkholderia sp. AIP Conference Proceedings, 2972(1). https://doi.org/10.1063/5.0182735

Frediansyah, A., & Fitriany, D. S. (2025). Halobacillus as source of natural products and enzyme factories. Extremophiles, 29(3), 34. https://doi.org/10.1007/s00792-025-01400-7

Frediansyah, A., Kurniadi, M., Helmi, R. L., Nurhikmat, A., & Susanto, A. (2018). Formula starter mengandung Lactobacillus plantarum untuk pembuatan mokaf dan proses pembuatannya (Patent No. IDP000053695). Direktorat Jenderal Kekayaan Intelektual.

Frediansyah, A., Kurniadi, M., Putri, N. N. N., & Prasedya, E. S. (2019). The kinetics of enzymes that involved in cassava fermentation produce by co-culture starter of two lactic acid bacteria. AIP Conference Proceedings, 2194(1). https://doi.org/10.1063/1.5141280

Frediansyah, A., Kurniadi, M., Susanto, A., Restuti, A., & Angwar, M. (2018). Kecap organik dan proses pembuatannya (Patent No. P00201810175). Direktorat Jenderal Kekayaan Intelektual.

Frediansyah, A., & Kurniadi, M. (2016). Comparative influence of salinity and temperature on cassava flour product by Lactobacillus plantarum and Lactobacillus acidophilus during single culture fermentation. Nusantara Bioscience, 8(2), 207–214. https://doi.org/10.13057/nusbiosci/n080212

Frediansyah, A., & Kurniadi, M. (2017). Michaelis kinetic analysis of extracellular cellulase and amylase excreted by Lactobacillus plantarum during cassava fermentation. AIP Conference Proceedings, 1868(1). https://doi.org/10.1063/1.4968364

Frediansyah, A., Nurhayati, R., & Romadhoni, F. (2017). Enhancement of antioxidant activity, a-glucosidase and a-amylase inhibitory activities by spontaneous and bacterial monoculture fermentation of Indonesian black grape juices. In AIP Conference Proceedings (Vol. 1803, Article 020036). AIP Publishing. https://doi.org/10.1063/1.4973149

Frediansyah, A., Manuhara, Y. S. W., Kristanti, A. N., Luqman, A., & Wibowo, A. T. (2022). Fermentation in minimal media and fungal elicitation enhance violacein and deoxyviolacein production in two Janthinobacterium strains. Fermentation, 8(12), 714. https://doi.org/10.3390/fermentation8120714

Frediansyah, A., Miess, H., Cleenwerck, I., & Gross, H. (2023). Genome sequences of the two Telluria type strains, Telluria chitinolytica ACM 3522^T^ and Telluria mixta DSM 29330^T^. Microbiology Resource Announcements, 12(7), e00215-23. https://doi.org/10.1128/mra.00215-23

Frediansyah, A., Miftakhussolikhah, Kurniadi, M., Susanto, A., & Poelongasih, C. D. (2014). Determinasi kandungan folat tepung tempe kedelai varietas Baluran pada berbagai variasi proses. In M. Yudiarti, E. Soekarti, S. Muslimatun, Purwanto, M. Ariani, Hardinayah, Y. Egayanti, & L. B. Kardono (Eds.), Widyakarya Nasional Pangan dan Gizi X. LIPI Press.

Frediansyah, A., Nainu, F., Dhama, K., Mudatsir, M., & Harapan, H. (2021). Remdesivir and its antiviral activity against COVID-19: A systematic review. Clinical Epidemiology and Global Health, 9, 123–127. https://doi.org/10.1016/j.cegh.2020.07.011

Frediansyah, A., Nufus, H., Nugroho, I. B., & Gross, H. (2026). Complete genome sequence of Halobacillus sp. strain 12SKB, a carotenoid-producing bacterium isolated from Kakaban Lake, an anchialine lagoon within a raised atoll in East Kalimantan, Indonesia. Microbiology Resource Announcements. e01139-25. https://doi.org/10.1128/mra.01139-25

Frediansyah, A., Nufus, H., Pramono, A. K., Siregar, A. R., & Gross, H. (2026). Whole-genome sequence of Kocuria rhizophila 01AKB, an endophyte from the green macroalga Halimeda sp. in Kakaban Lake, Borneo, Indonesia. Microbiology Resource Announcements. https://doi.org/10.1128/mra.00284-26

Frediansyah, A., Romadhoni, F., Suryani, Nurhayati, R., & Wibowo, A. T. (2021). Fermentation of Jamaican cherries juice using Lactobacillus plantarum elevates antioxidant potential and inhibitory activity against type II diabetes-related enzymes. Molecules, 26(10), 2868. https://doi.org/10.3390/molecules26102868

Frediansyah, A., Sallam, M., Sallam, M., Sallam, M., Yufika, A., Sharun, K., Iqhrammullah, M., Chandran, D., Mamada, S. S., Sallam, D. E., Khader, Y., Lemu, Y. K., Yusuf, F., Kretchy, J. P., Abdeen, Z., Torres-Roman, J. S., Acharya, Y., Bondarenko, A., Ikram, A., … Harapan, H. (2022). Acute severe hepatitis of unknown etiology in children: A mini review. Narra J, 2(2), e83. https://doi.org/10.52225/narra.v2i2.83

Frediansyah, A., Sofyantoro, F., Alhumaid, S., Al Mutair, A., Albayat, H., Altaweil, H. I., Al-Afghani, H. M., AlRamadhan, A. A., AlGhazal, M. R., Turkistani, S. A., Abuzaid, A. A., & Rabaan, A. A. (2022). Microbial natural products with antiviral activities, including anti-SARS-CoV-2: A review. Molecules, 27(13), 4305. https://doi.org/10.3390/molecules27134305

Frediansyah, A., Straetener, J., Brötz-Oesterhelt, H., & Gross, H. (2021). Massiliamide, a cyclic tetrapeptide with potent tyrosinase inhibitory properties from the gram-negative bacterium Massilia albidiflava DSM 17472^T^. The Journal of Antibiotics, 74(4), 269–272. https://doi.org/10.1038/s41429-020-00394-y

Frediansyah, A., & Sudiana, I. M. (2013). The potential of Paenibacillus spp. as a plant growth promoter in tropical peat ecosystems. Widyariset, 16(2). https://www.researchgate.net/profile/Andri_Frediansyah/publication/259849308_The_Potential_of_Paenibacillus_spp_as_Plant_Growth_Promoter_in_Tropical_Peat_Ecosystem/links/58aaa7e7a6fdcc0e07983e92/The-Potential-of-Paenibacillus-spp-as-Plant-Growth-Promoter-in-Tropical-Peat-Ecosystem.pdf

Frediansyah, A., Suryani, Nurhayati, R., Miftakhussolikhah, & Sholihah, J. (2019). Lactobacillus pentosus isolated from Muntingia calabura shows inhibition activity toward alpha-glucosidase and alpha-amylase in intra and extracellular level. IOP Conference Series: Earth and Environmental Science, 251(1). https://doi.org/10.1088/1755-1315/251/1/012003

Frediansyah, A., Tiwari, R., Sharun, K., Dhama, K., & Harapan, H. (2021). Antivirals for COVID-19: A critical review. Clinical Epidemiology and Global Health, 9, 90–98. https://doi.org/10.1016/j.cegh.2020.07.011

Gumulya, Y., Peng, H., Ebert, B. E., Johnson, H., van der Pols, J. C., Bansal, N., Marcellin, E., & Turner, M. S. (2025). Advancing Australia’s food future: Opportunities and challenges in precision fermentation. Future Foods, 11(100630), 100630. https://doi.org/10.1016/j.fufo.2025.100630

Guo, Q., Chen, P., & Chen, X. (2023). Bioactive peptides derived from fermented foods: Preparation and biological activities. Journal of Functional Foods, 101(105422), 105422. https://doi.org/10.1016/j.jff.2023.105422

Hadinata, E., Harbuwono, D. S., Soegondo, S., Prajitno, J. H., Mudjanarko, S. W., Taslim, N. A., Hasyyati, E. Y., Frediansyah, A., Surya, R., Cahyono, M. B. A., & Santini, A. (2025). Marine nutraceuticals as a source of SIRT1 and NRF2 activators for diabetes and aging-related metabolic disorders. Diabetology & Metabolic Syndrome, 17(1), 1–31. https://doi.org/10.1186/s13098-025-01981-5

Hussain, M. H., Mohsin, M. Z., Zaman, W. Q., Yu, J., Zhao, X., Wei, Y., Zhuang, Y., Mohsin, A., & Guo, M. (2022). Multiscale engineering of microbial cell factories: A step forward towards sustainable natural products industry. Synthetic and Systems Biotechnology, 7(1), 586–601. https://doi.org/10.1016/j.synbio.2021.12.012

Ikhsanudin, A., Habibie, A., Pratiwi, S. U. T., Pujianto, D. A., Frediansyah, A., & Retnaningrum, E. (2025). Metabolite profiling and anti-multidrug-resistant activity of Streptomyces anulatus ACSAN21-05 isolated from Indonesian mangrove rhizosphere. Trends in Sciences, 22(11), 10533. https://doi.org/10.48048/tis.2025.10533

INDEF. (2025). Ketahanan pangan dan energi Indonesia di tengah perang tarif. Institute for Development of Economics and Finance, Center of Food, Energy and Sustainable Development.

Jiao, J., Du, J., Frediansyah, A., Jahanshah, G., & Gross, H. (2020). Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli. The Journal of Antibiotics, 73(1), 28–34. https://doi.org/10.1038/s41429-019-0246-0

Kawamoto, M., Jouraku, A., Toyoda, A., Yokoi, K., Minakuchi, Y., Katsuma, S., Fujiyama, A., Kiuchi, T., Yamamoto, K., & Shimada, T. (2019). High-quality genome assembly of the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 107, 53–62. https://doi.org/10.1016/j.ibmb.2019.02.002

Kim, G. B., Kim, H. R., & Lee, S. Y. (2025). Comprehensive evaluation of the capacities of microbial cell factories. Nature Communications, 16(1), 2869. https://doi.org/10.1038/s41467-025-58227-1

Kurniadi, M., Afuw, H. A., Sari, A. M., Wiyono, T., Nurhayati, R., & Frediansyah, A. (2021). Effect of Saccharomyces cerevisiae fermentation on the quality of Samurai 2, a mutant sorghum flour. International Food Research Journal, 28(3), 603–611. https://doi.org/10.47836/ifrj.28.3.20

Marcellin, E., Bansal, N., Ebert, B., Gumulya, Y., Johnson, H., Peng, H., Turner, M., & Van Der Pols, J. (2024). Precision fermentation: A future of food in Australia, white paper. Innovative Ingredients Program, Australia’s Food and Beverage Accelerator (FaBA).

Mamada, S. S., Nainu, F., Masyita, A., Frediansyah, A., Utami, R. N., Salampe, M., Emran, T. Bin, Lima, C. M. G., Chopra, H., & Simal-Gandara, J. (2022). Marine macrolides to tackle antimicrobial resistance of Mycobacterium tuberculosis. Marine Drugs, 20(11), 691. https://doi.org/10.3390/md20110691

Miess, H., Frediansyah, A., Göker, M., & Gross, H. (2020). Draft genome sequences of six type strains of the genus Massilia. Microbiology Resource Announcements, 9(18), e00226-20. https://doi.org/10.1128/mra.00226-20

Miller, A. L., Renye, J. A., Jr, Oest, A. M., Liang, C., Garcia, R. A., Plumier, B. M., & Tomasula, P. M. (2024). Bacteriocin production by lactic acid bacteria using ice cream co-product as the fermentation substrate. Journal of Dairy Science, 107(6), 3468–3477. https://doi.org/10.3168/jds.2023-24249

Mudondo, J., Happy, K., Gang, R., Ban, Y., & Kang, Y. (2025). From nature to nutrition: Exploring the synergistic benefits of functional foods and herbal medicines for holistic health. Applied Biological Chemistry, 68(1). https://doi.org/10.1186/s13765-025-00985-z

Nainu, F., Abidin, R. S., Bahar, M. A., Frediansyah, A., Emran, T. B., Rabaan, A. A., Dhama, K., & Harapan, H. (2020). SARS-CoV-2 reinfection and implications for vaccine development. Human Vaccines & Immunotherapeutics, 16(12), 3061–3073. https://doi.org/10.1080/21645515.2020.1830683

Ndraha, N., Damayanti, E., Frediansyah, A., Ndraha, V., & Aditya, S. (2026). Enhancing microbial food safety in Indonesia’s artisanal cheese sector: A strategic framework for consumer protection. Journal of Consumer Protection and Food Safety. Advance online publication. https://doi.org/10.1007/s00003-025-01592-2

NSF. (2024, April 24). Corrections: Seven degrees from one trillion species of microbes. U.S. National Science Foundation. https://www.nsf.gov/news/seven-degrees-one-trillion-species-microbes

Nurhayati, R., Frediansyah, A., Rahmawati, F., & Retnaningrum, E. (2015, October 30–31). Screening of a-glucosidase inhibitor-producing lactic acid bacteria from Ganoderma lucidum as functional food candidate for diabetic [Paper presentation]. 1st International Conference on Appropriate Technology Development (ICATDEV), Bandung, Indonesia.

Nurhayati, R., Miftakhussolikhah, Frediansyah, A., & Rachmah, D. L. (2017). Lactic acid bacteria producing inhibitor of alpha glucosidase isolated from ganyong (Canna edulis) and kimpul (Xanthosoma sagittifolium). IOP Conference Series: Earth and Environmental Science, 101(1), 012009. https://doi.org/10.1088/1755-1315/101/1/012009

Nurkolis, F., Nishani, F., Daliu, P., Aziziy, Y. N., Aziz, S. A. A., Simanjuntak, A. M. T., Nufus, H., Prasedya, E. S., Santini, A., & Frediansyah, A. (2025). Sargassum polycystum as natural source of antioxidant and antidiabetic compounds: A solvent-driven metabolomic profiling study. Journal of Agriculture and Food Research, 102549. https://doi.org/10.1016/j.jafr.2025.102549

Nurkolis, F., Aldian, F. M., Alfaray, R. I., Johan, A. R. D., Frediansyah, A., Permatasari, H. K., Taslim, N. A., Tjandrawinata, R. R., Mustika, A., Kim, B., & Santini, A. (2025). Integrative pharmacoinformatic and experimental validation of Indonesian red algae as novel functional food for anti-gastric cancer agents. Molecular Nutrition & Food Research, 69(23), e70282. https://doi.org/10.1002/mnfr.70282

Nurmilah, S., Frediansyah, A., Cahyana, Y., & Utama, G. L. (2024). Biotransformation and health potential of isoflavones by microorganisms in Indonesian traditional fermented soy products: A review. Journal of Agriculture and Food Research, 18, 101365. https://doi.org/10.1016/j.jafr.2024.101365

Nurmilah, S., Frediansyah, A., Cahyana, Y., Balia, R. L., Andriana, B. B., & Utama, G. L. (2025). Exploring microbial dynamics and metabolomic profiling of isoflavone transformation in black and yellow soybean tempe for sustainable functional foods. Food Chemistry: Molecular Sciences, 11, 100279. https://doi.org/10.1016/j.fochms.2025.100279

Pal, G. (2025). Mitigating the effects of climate change on indigenous fermented foods: Strategies for the future. In Disaster resilience and green growth (pp. 79–102). Springer Nature Singapore. https://doi.org/10.1007/978-981-96-9286-6_4

Prihanto, A. A., Umam, N. I., & Bangun, J. D. G. (2024). Unveiling the secrets of Indonesian fermented fish: Characteristics of lactic acid bacteria, roles, and potential in product development. Food Bioscience, 61, 104629. https://doi.org/10.1016/j.fbio.2024.104629

Prasedya, E. S., Syafitri, S. M., Geraldine, B. A. F. D., Hamdin, C. D., Frediansyah, A., Miyake, M., Kobayashi, D., Hazama, A., & Sunarpi, H. (2019). UVA photoprotective activity of brown macroalgae Sargassum cristafolium. Biomedicines, 7(4), 77. https://doi.org/10.3390/biomedicines7040077

Prasedya, E. S., Martyasari, N. W. R., Abidin, A. S., Pebriani, S. A., Ilhami, B. T. K., Frediansyah, A., Sunarwidhi, A. L., Widyastuti, S., & Sunarpi, H. (2020). Macroalgae Sargassum cristaefolium extract inhibits proinflammatory cytokine expression in BALB/C Mice. Scientifica, 2020, 9769454. https://doi.org/10.1155/2020/9769454

Prasedya, E. S., Ardiana, N., Padmi, H., Ilhami, B. T. K., Martyasari, N. W. R., Sunarwidhi, A. L., Nikmatullah, A., Widyastuti, S., Sunarpi, H., & Frediansyah, A. (2021). The antiproliferative and apoptosis-inducing effects of the red macroalgae Gelidium latifolium extract against melanoma cells. Molecules, 26(21), 6568. https://doi.org/10.3390/molecules26216568

Prasedya, E. S., Frediansyah, A., Martyasari, N. W. R., Ilhami, B. K., Abidin, A. S., Padmi, H., Fahrurrozi, Juanssilfero, A. B., Widyastuti, S., & Sunarwidhi, A. L. (2021). Effect of particle size on phytochemical composition and antioxidant properties of Sargassum cristaefolium ethanol extract. Scientific Reports, 11(1), 17874. https://doi.org/10.1038/s41598-021-95769-y

Prasedya, E. S., Padmi, H., Ilhami, B. T. K., Martyasari, N. W. R., Sunarwidhi, A. L., Widyastuti, S., Khairinisa, M. A., Cokrowati, N., Simangunsong, E. E., & Frediansyah, A. (2022). Brown macroalgae Sargassum cristaefolium extract inhibits melanin production and cellular oxygen stress in B16F10 melanoma cells. Molecules, 27(23), 8585. https://doi.org/10.3390/molecules27238585

Prasedya, E. S., Saraswati, P. B. A., Martyasari, N. W. R., Frediansyah, A., Khalil, M., & Widyastuti, S. (2025). Ethyl acetate extract from red coralline macroalgae Mastophora rosea, rich in polyphenolic catechins, induces apoptosis and inhibits metastasis in melanoma cell line. *Beni-Suef University Journal of Basic and Applied Sciences, 14*(1), 77. https://doi.org/10.1186/s43088-025-00621-1

Purwanto, E. H., Frediansyah, A., Fitrianto, N., Palindung, L. S., Marwati, T., Santoso, T. J., Susilawati, L., Khodija, S., Rachmawati, F., & Wibowo, N. A. (2024). Partial purification and pectinase activity of lactic acid bacteria and pectinolytic bacteria consortium. In IOP Conference Series: Earth and Environmental Science (Vol. 1377, Article 012048). IOP Publishing. https://doi.org/10.1088/1755-1315/1377/1/012048

Rappuoli, R., Young, P., Ron, E., Pecetta, S., & Pizza, M. (2023). Save the microbes to save the planet. A call to action of the International Union of the Microbiological Societies (IUMS). One Health Outlook, 5(1), 5. https://doi.org/10.1186/s42522-023-00077-2

Rivaldi, M., Frediansyah, A., Aziz, S. A. A., & Nugroho, A. P. (2025). Active biomonitoring of stream ecosystems: Untargeted metabolomic and proteomic responses and free radical scavenging activities in mussels. Ecotoxicology, 34(3), 425–443. https://doi.org/10.1007/s10646-024-02846-9

Rohman, A., Maritha, V., Windarsih, A., Budikafa, M. J., Riswanto, F. D. O., Munir, M. A., & Rahmania, H. (2025). The use of metabolomics approach in the combination with multivariate data analysis for the identification of non-halal meats: A narrative review. Food Science of Animal Resources, 45(6), 1553–1569. https://doi.org/10.5851/kosfa.2025.e36

Saad, H., Aziz, S., Gehringer, M., Kramer, M., Straetener, J., Berscheid, A., Brötz-Oesterhelt, H., & Gross, H. (2021). Nocathioamides, uncovered by a tunable metabologenomic approach, define a novel class of chimeric lanthipeptides. Angewandte Chemie International Edition, 60(30), 16472–16479. https://doi.org/10.1002/anie.202102571

Safitri, I. O., Agnesty, D., Sihombing, J., Ramadaningrum, W. A., Harsanto, B. W., Leliana, L., & Frediansyah, A. (2025). Naniura: A traditional Batak fermented fish as a source of lactic acid bacteria and functional bioactives—A comprehensive review. International Journal of Gastronomy and Food Science, 101402. https://doi.org/10.1016/j.ijgfs.2025.101402

Safrienda, A. R., Kurnianto, D., Jasmadi, J., & Frediansyah, A. (2023). Cassava and microalgae use in the food industry: Challenges and prospects. In A. Frediansyah (Ed.), Cassava - Recent updates on food, feed, and industry (pp. 1–22). IntechOpen. https://doi.org/10.5772/intechopen.110518

Sampsell, K., Marcolla, C. S., Tapping, S., Fan, Y., Sánchez-Lafuente, C. L., Willing, B. P., Reimer, R. A., & Burton, J. P. (2025). Current research in fermented foods: Bridging tradition and science. Advances in Nutrition, 16(12), 100554. https://doi.org/10.1016/j.advnut.2025.100554

Setiarto, R. H. B., Octaviana, S., Perwitasari, U., Juanssilfero, A. B., & Suprapedi, S. (2024). Development of functional bioflavor based on Indonesian indigenous microbial fermentation products. Journal of Ethnic Foods, 11(1). https://doi.org/10.1186/s42779-024-00242-6

Siddiqui, S. A., Erol, Z., Rugji, J., Tasci, F., Kahraman, H. A., Toppi, V., Musa, L., Di Giacinto, G., Bahmid, N. A., Mehdizadeh, M., & Castro-Muñoz, R. (2023). An overview of fermentation in the food industry - looking back from a new perspective. Bioresources and Bioprocessing, 10(1), 85. https://doi.org/10.1186/s40643-023-00702-y

Sofyantoro, F., & Frediansyah, A. (2025). Isoflavone aglycones: Sources, bioavailability enhancement strategies, and health benefits. Journal of Food Composition and Analysis, 148, 108613. https://doi.org/10.1016/j.jfca.2025.108613

Sofyantoro, F., Prasedya, E. S., Nurkolis, F., & Frediansyah, A. (2025). Exploring the nutritional and bioactive potential of microalgal sulfated polysaccharides for functional food applications. Food Science and Biotechnology. Advance online publication. https://doi.org/10.1007/s10068-025-02031-6

Sunarwidhi, A. L., Hernawan, A., Frediansyah, A., Widyastuti, S., Martyasari, N. W. R., Abidin, A. S., Padmi, H., Handayani, E., Utami, N. W. P., Maulana, F. A., Ichfa, M. S. M., & Prasedya, E. S. (2022). Multivariate analysis revealed ultrasonic-assisted extraction improves anti-melanoma activity of non-flavonoid compounds in Indonesian brown algae ethanol extract. Molecules, 27(21), 7509. https://doi.org/10.3390/molecules27217509

Sunaryanto, R., Basuki, W., Frediansyah, A., Perdana, E. G., Lentaya, H. O., & Andriana, Y. (2024). Formulasi minuman jamu beras kencur yang mengandung probiotik dan proses pembuatannya (Patent No. P00202408719). Direktorat Jenderal Kekayaan Intelektual.

Temple, N. J. (2022). A rational definition for functional foods: A perspective. Frontiers in Nutrition, 9, 957516. https://doi.org/10.3389/fnut.2022.957516

Verma, K., Duhan, P., Pal, D., Verma, P., & Bansal, P. (2025). Precision fermentation for the next generation of food ingredients: Opportunities and challenges. Future Foods, 12, 100750. https://doi.org/10.1016/j.fufo.2025.100750

Wahyudi, D. N., Lara Utama, G., & Frediansyah, A. (2024). Tofu wastewater recovery for mannoprotein production from yeast and mold cell walls. International Journal of Food Properties, 27(1), 1247–1264. https://doi.org/10.1080/10942912.2024.2398006

Wiyono, T., Frediansyah, A., Sholikhah, E. N., & Pratiwi, W. R. (2022). UHPLC-ESI-MS analysis of Javanese Tamarindus indica leaves from various tropical zones and their beneficial properties in relation to antiobesity. Journal of Applied Pharmaceutical Science, 12(8), 137–147. https://doi.org/10.7324/JAPS.2022.120814

Wu, Q., Zhu, Y., Fang, C., Wijffels, R. H., & Xu, Y. (2021). Can we control microbiota in spontaneous food fermentation? – Chinese liquor as a case example. Trends in Food Science & Technology, 110, 321–331. https://doi.org/10.1016/j.tifs.2021.02.011

Yee, C. S., Zahia-Azizan, N. A., Abd Rahim, M. H., Mohd Zaini, N. A., Raja-Razali, R. B., Ushidee-Radzi, M. A., Ilham, Z., & Wan-Mohtar, W. A. A. Q. I. (2025). Smart fermentation technologies: Microbial process control in traditional fermented foods. Fermentation, 11(6), 323. https://doi.org/10.3390/fermentation11060323

Zdouc, M. M., Blin, K., Louwen, N. L. L., Navarro, J., Loureiro, C., Bader, C. D., Bailey, C. B., Barra, L., Booth, T. J., Bozhuyuk, K. A. J., Cediel-Becerra, J. D. D., Charlop-Powers, Z., Chevrette, M. G., Chooi, Y. H., D’Agostino, P. M., de Rond, T., Del Pup, E., Duncan, K. R., Gu, W., … Frediansyah, A., … Medema, M. H. (2025). MIBiG 4.0: Advancing biosynthetic gene cluster curation through global collaboration. Nucleic Acids Research, 53(D1), D678–D690. https://doi.org/10.1093/nar/gkae1115

Zhu, S., Xu, H., Liu, Y., Hong, Y., Yang, H., Zhou, C., & Tao, L. (2025). Computational advances in biosynthetic gene cluster discovery and prediction. Biotechnology Advances, 79, 108532. https://doi.org/10.1016/j.biotechadv.2025.108532